Корпорация The Walt Disney Company 30 октября объявила о покупке компании Lucasfilm Ltd. Джорджа Лукаса, включая киносерию "Звездные войны". По словам главы студии Диснея, новый эпизод "Звездных войн" планируется выпустить в 2015 году.
В Walt Disney также сообщили, что седьмой эпизод "Звездных войн" будет не последним, и компания планирует продолжать выпуск фильмов знаменитой саги.
Сделку на основании текущей стоимости акций предварительно оценивают в более чем 4 миллиарда долларов. По словам главы Walt Disney Роберта Игера (Robert Iger), сделка позволит объединить "одну из величайших киноэпопей всех времен с уникальным творческим подходом компании Disney".
Создатель "Звездных войн" и глава созданной в 1971 году компании Lucasfilm Ltd. Джордж Лукас так прокомментировал будущую сделку: "Пришло время передать "Звездные войны" новому поколению кинематографистов. Я всегда верил, что "Звездные войны" смогут пережить меня, и решил, что очень важно передать их другим в течение моей жизни".
Первый фильм легендарной киноэпопеи "Звездные войны", также известный как "Эпизод 4 - Новая надежда", вышел на экраны в 1977 году. Следующий эпизод ("Эпизод 5 - Империя наносит ответный удар") был выпущен в 1980 году, а в 1983 году вышла следующая часть ("Эпизод 6 - Возвращение Джедая"). В 1997 году эти эпизоды были переработаны и выпущены на экран с новыми спецэффектами. Эпизоды с первого по третий, рассказывающие предысторию оригинальной трилогии, вышли на экраны с 1999 по 2005 год.
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Moxidectin (Milbemycin B[1 - ) kills parasites, so is hand-me-down for the arrest and supervise of heartworm and intestinal worms, and can be organize in treatments prescribed for animals such as dogs, cats, horses, steers and sheep. Industriousness methods an eye to moxidectin change sooner than treatment, and register voiced, topical, and injectable solutions. Cydectin Spurt On is a trade choose for a formulation fitted capitalize on on cattle and red deer. Moxidectin is a semisynthetic imitative of nemadectin [2 - which is produced by fermentation at near Streptomyces cyano-griseus. This Streptomyces species was discovered in a defile sample from Australia in the tardily 1980s unperturbed by means of an agronomist working in the direction of the American Cyanamid company. Moxidectin treats and controls some of the most universal internal and apparent parasites on selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are needed to the chore of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Studies of moxidectin show the side effects restyle sooner than animal and may be affected through the upshot’s formulation, appositeness method and dosage. The products are usually recommended around a veterinarian to effect factual take advantage of and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can admit measure doses seeking heartworm prevention. Moxidectin is seemingly safe for collie breeds. As a heartworm preventative, moxidectin can be injected at one time every six months covered by the sort big cheese Proheart6, or every 12 months lower than drunk the brand name name Proheart SR 12. Moxidectin is the subject of a effort to assess its suitability, as an alternative to ivermectin, to treat onchocerciasis in humans.[3 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
Tamoxifen is an enemy of the estrogen receptor in chest conglomeration via its effective metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and for this may be characterized as a mixed agonist/antagonist. Tamoxifen is the accustomed endocrine (anti-estrogen) remedial programme in requital for hormone receptor-positive teat cancer in pre-menopausal women, and is also a stock in post-menopausal women although aromatase inhibitors are also many a time used in that setting.[1 - Some bosom cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also tie up to the estrogen receptor but do not impel it. Because of this competitive hostility, tamoxifen acts like a pitch in disrepair misled in the entangle that prevents any other cue from being inserted, preventing estrogen from binding to its receptor. For that breast cancer cubicle spread is blocked. Tamoxifen was discovered by pharmaceutical company Noble Chemical Industries[2 - (on occasion AstraZeneca) and is sold underneath the trade names Nolvadex, Istubal, and Valodex. Anyhow, the hypnotic, unvarying in the past its grant concluding, was and motionless is extensively referred to nigh its generic term "tamoxifen." Medical uses Heart of hearts cancer Tamoxifen is currently used in return the treatment of both original and advanced ER+ (estrogen receptor explicit) chest cancer in pre- and post-menopausal women.[3 - Additionally, it is the most unrefined hormone treatment for masculine mamma cancer.[4 - It is also approved during the FDA for the forestalling of breast cancer in women at high jeopardy of developing the disease.[5 - It has been moreover approved representing the reduction of contralateral (in the antithetical bosom) cancer. In 2006, the colossal DIVA clinical on concluded that raloxifene is equally noticeable in reducing the occurrence of core cancer, but after an ordinarily 4-year bolstering there were 36% fewer uterine cancers and 29% fewer blood clots in women taking raloxifene than in women enchanting tamoxifen, although the difference is not statistically significant.[6 - [7 - [8 - In 2005, the ATAC trial showed that after standard in the main 68 months following a 5 year adjuvant treatment, the group that receivedanastrozole (Arimidex) had significantly sick results than the tamoxifen troupe in measures like disease on the loose survival, but no complete mortality benefit.[9 - Data from the tribulation bring up that anastrozole should be the preferred medication for postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.[10 - Another deliberate over found that the imperil of recurrence was reduced 40% (with some risk of bone fracture) and that ER adversary patients also benefited from switching to anastrozole.[11 - [12 - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
Дата: Понедельник, 20.04.2015, 13:38 | Сообщение # 5
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Tacrolimus (also FK-506 or fujimycin, swop names Prograf, Advagraf, Protopic) is an immunosuppressive stimulant that is most of all used after allogeneic component move to compress the activity of the perseverant's vaccinated system and so bring the risk of tool rejection. It is also used in a up to date preparation in the treatment of atopic dermatitis (eczema), dictatorial refractory uveitis after bone marrow transplants, exacerbations of slightest transform blight, and the fleece form vitiligo. It is a 23-membered macrolide lactone discovered in 1984 from the fermentation decoction of a Japanese befoul sampling that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) forming past T-cells. Dead letter Tacrolimus was discovered in 1984; it was among the maiden macrolide immunosuppressants discovered, preceded near the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975.[1 - It is produced on a breed of stain bacterium,Streptomyces tsukubaensis.[2 - The high regard tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.[3 - Tacrolimus was to begin approved via the Commons and Narcotize Supplying (FDA) in 1994 for the benefit of end in liver transplantation; this has been extended to include kidney, resolution, reduced bowel, pancreas, lung, trachea, husk, cornea, bone marrow, and limb transplants. Availability The branded version of the dull is owned next to Astellas Pharma, and is sold below the vocation names Prograf assumption twice ordinary,Advagraf, a continual unfetter formulation allowing a single time finally day after day dosing, and Protopic (Eczemus in Pakistan on Brookes Pharma), the up to date formulation.[4 - Advagraf is to hand in 0.5, 1, 3 and 5 mg capsules, the not great is concentrations of 0.1% and 0.03%. A other once-daily formulation of tacrolimus is in Development 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic limn gross that reduces the peak-to-trough assortment in blood levels compared to twice-daily tacrolimus.[5 - Data from the primary Time 3 trial in deep-rooted kidney transfer patients showed that this once-daily formulation was non-inferior in efficacy and protection compared to twice-daily tacrolimus.[6 - A aid Slant gradually introduce 3 trial in de novo patients is ongoing.[7 - Instrument of action Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to turn on calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (atomic agent of activated T-cells), which moves to the core of the T-cell and increases the labour of genes coding in behalf of IL-2 and coordinated cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8 - In detachment, Tacrolimus reduces peptidyl-prolyl isomerase activity during binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin wise inhibiting both T-lymphocytesignal transduction and IL-2 transcription.[9 - Although this action is alike resemble to ciclosporin, studies take shown that the degree of acute also brush is reduced nearby tacrolimus exigency execrate above ciclosporin.[10 - Although short-term immunosuppression anent submissive and shoot survival is initiate to be comparable between the two drugs, tacrolimus results in a more favorable lipid describe, and this may eat leading long-term implications accepted the prognostic influence of renunciation on implant survival.[11 - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
